Seasonal Effects on Gene Expression

Seasonal Effects on Gene Expression

Many health conditions, ranging from psychiatric disorders to cardiovascular disease, display notable seasonal variation in severity and onset. In order to understand the molecular processes underlying this phenomenon, we have examined seasonal variation in the transcriptome of 606 healthy individuals. We show that 74 transcripts associated with a 12-month seasonal cycle were enriched for proce...

Photoperiodic Effects on Seasonal Physiology, Reproductive Status and Hypothalamic Gene Expression in Young Male F344 Rats

Seasonal or photoperiodically sensitive animals respond to altered day length with changes in physiology (growth, food intake and reproductive status) and behaviour to adapt to predictable yearly changes in the climate. Typically, different species of hamsters, voles and sheep are the most studied animal models of photoperiodism. Although laboratory rats are generally considered nonphotoperiodi...

Alcohol’s Effects on Gene Expression

Altering the expression of specific genes in the brain is one of the mechanisms through which the organism may adapt to chronic alcohol exposure. Several molecular biology methods allow researchers to isolate alcohol­regulated genes from cultured cells or laboratory animals. These techniques have led to the identification of numerous genes whose expression is increased or decreased in cells tha...

Circulat Effects on Gene Expression in Fibroblasts

Circulat is a systemic standardized plant extract formulation that was developed for the prevention of severe manifestations of type 2 diabetes such as necrotic damage of the plantar foot. With the aim of revealing the molecular mechanisms underlying Circulat’s biological activity, the effects of Circulat treatment on gene expression levels were examined in the cultured human fibroblast cell li...

Effects of cannabinoids on gene expression.